A p105-based Inhibitor Broadly Represses NF-κB Activities
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چکیده
منابع مشابه
Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis.
The mechanisms that govern proteolytic maturation or complete destruction of the precursor proteins p100 and p105 are fundamental to homeostasis and activation of NF-κB; however, they remain poorly understood. Using mass-spectrometry-based quantitative analysis of noncanonical LTβR-induced signaling, we demonstrate that stimulation induces simultaneous processing of both p100 and p105. The prec...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m312572200